CARDIOVASCULAR DISEASES IN PATIENTS WITH DIABETES MELLITUS
Keywords:
diabetes mellitus, hyperglycemia, endothelial dysfunction, cardiovascular diseasesAbstract
The review pays attention to a considerable rise in the incidence of diabetes mellitus (DM) and to its as- sociation with cardiovascular diseases (CVD) and events. It is noted that these events may be present much earlier than DM is diagnosed. The paper also discusses in detail a role of hyperglycemia, postprandial one in particular, hy- perinsulinemia, insulin resistance, endothelial dysfunction, impaired blood rheological properties, lipid metabolic disturbances, and genetic and traditional risk factors in the development of atherosclerosis, coronary heart disease, chronic heart failure, cerebrovascular diseases, and lower extremity ischemia in DM.